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Related Experiment Videos

Digitalis and baroreceptor reflexes in man.

A Ferrari, L Gregorini, M C Ferrari

    Circulation
    |February 1, 1981
    PubMed
    Summary

    Therapeutic digitalis doses in humans enhance arterial baroreflexes, particularly the heart rate and blood pressure responses to baroreceptor stimulation. This effect was observed in both normotensive and hypertensive individuals.

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    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Animal studies suggest digitalis potentiates arterial baroreflexes, influencing cardiovascular effects.
    • Understanding this potentiation in humans at therapeutic doses is crucial.

    Purpose of the Study:

    • To investigate if therapeutic doses of digitalis enhance arterial baroreflexes in humans.
    • To assess the impact of digitalis on heart rate and blood pressure responses to baroreceptor manipulation.

    Main Methods:

    • Studied 29 normotensive/hypertensive subjects before and after intravenous Lanatoside C (0.8 mg).
    • Assessed arterial baroreceptor reflexes using phenylephrine, nitroglycerin, neck suction, and neck pressure.
    • Monitored heart rate and blood pressure changes.

    Main Results:

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    • Baroreceptor stimulation (phenylephrine, neck suction) significantly increased its bradycardic and hypotensive effects post-digitalis.
    • Baroreceptor deactivation (nitroglycerin, neck pressure) did not show significant changes in tachycardic and hypertensive responses.
    • Digitalis enhanced reflex responses more with stimulation than deactivation.

    Conclusions:

    • Therapeutic doses of digitalis enhance arterial baroreflexes in humans, affecting both heart rate and blood pressure.
    • The enhancement is more pronounced during baroreceptor stimulation than deactivation.