Variation of the HL-A antigens during neoplasm evolution

The study deals with the tissue antigen frequency in a group of 1648 patients with different clinical forms of cancer, hospitalized in the Oncological Institute, Bucharest. The authors do not find a correlation between a tissue antigen predominance and the occurrence or development of a certain form of cancer. Nevertheless a loss of some tissue antigens was noticed in severe advanced cases with multiple metastases. This fact can be observed also in patients irradiated during serotypings or treated with cortisone. At least 5 weeks after irradiation or in patients with favourable response to the treatment, with temporary important remission, the recurrence of the histocompatibility antigens can be obtained in subsequent examinations.