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The effects of diphenylhydantoin on rat behavior
Psychopharmacology
|January 1, 1980
Abstract:
Animals were administered increasing doses of diphenylhydantoin (DPH) for 20 days. During withdrawal they were observed in an open field. The results suggest that chronic DPH administration leads to a central supersensitivity phenomenon. Possible interference of DPH with dopaminergic systems was discussed.