Ventilatory response to the PCO2 profile in chicken lungs

We investigated the influence of intrapulmonary chemoreceptors (IPC) on ventilatory movements in anesthetized chickens when PCO2 profiles along the parabronchi were changed. In all experiments the right lung was denervated, both lungs unidirectionally ventilated, and PaCO2 kept constant. In series 1 (7 birds), gas flow and the PCO2 profile in the left lung were reversed. PaCO2, PECO2 and ventilatory movements did not change. In Series 2 (4 birds), PCO2 in caudal regions of the innervated lung was elevated by increasing gas flow and P1CO2 from 0 to 21 Torr. Ventilatory movements did not change. In Series 3 (4 birds), either lung was over-ventilated with 7 or 49 Torr P1CO2, alternating the gases between lungs every 100 sec. Ventilatory movements changes with P1CO2 but much less than predicted from P1CO2 effects in the non-perfused, innervated lung. From the longitudinal distribution of IPC and PCO2 profiles in the lung we predicted moderate to large changes in ventilatory movements in all series. The discrepancy between predicted and observed results in Series 1 and 2 indicates that IPC in caudal regions of the lung have little effect on ventilation under the conditions examined. In Series 3, observed ventilatory movements were less sensitive to P1CO2 than predicted, indicating that IPC sense a different PCO2 than the PCO2 profile in the parabronchial lumen and that IPC have a significant sensitivity to pulmonary blood PCO2.