Hypergonadotrophic amenorrhoea

Hypergonadotrophic amenorrhoea implies permanent gonadal failure, This has intense psychological, sociological and practical implications for the patient, and an accurate diagnosis is therefore important. Moreover, it is a heterogeneous group including on the one hand some treatable entities and on the other some conditions which could be deleterious to the patient's general health. Although in the majority of patients a precise aetiological factor for the premature disappearance of the oöcytes cannot be identified, future research will most probably implicate immunological mechanisms.