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Related Experiment Videos

Increased fibrinopeptide A after prothrombin complex concentrates.

S Viganó, M Cattaneo, W Gervasoni

    Thrombosis and Haemostasis
    |October 31, 1980
    PubMed
    Summary

    Prothrombin complex concentrates (PCC) frequently activate the clotting mechanism, indicated by elevated fibrinopeptide A (FpA) levels in hemophilia patients. This suggests thrombin generation occurs often, despite rare clinical thromboembolism events.

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    Area of Science:

    • Hematology
    • Thrombosis and Hemostasis

    Background:

    • Prothrombin complex concentrates (PCC) are associated with thromboembolic risks.
    • Assessing in vivo clotting activation is crucial for patient safety.

    Purpose of the Study:

    • To reassess the risk of thromboembolism by detecting in vivo clotting activation after PCC administration.
    • To measure fibrinopeptide A (FpA) levels post-PCC infusion in hemophilic patients.

    Main Methods:

    • Measured FpA levels 15-60 minutes after PCC infusion in hemophilia B patients.
    • Compared FpA changes after activated PCC (FEIBA, Auto IX) in hemophilia A patients with inhibitors.
    • Used F. VIII concentrates as a control in hemophilia A patients.

    Main Results:

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  • Significant FpA increase observed after 19 PCC infusions in 14 hemophilia B patients.
  • More pronounced FpA increase after FEIBA and Auto IX in 4 hemophilia A patients.
  • No significant FpA change in 7 hemophilia A patients receiving F. VIII concentrates.

    • Conclusions:

    • PCC administration frequently leads to thrombin circulation in hemophilic patients.
    • Clinical thromboembolism appears rare despite frequent laboratory evidence of clotting activation.