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Eggshell calcification of lymph nodes: an update.

B H Gross, H J Schneider, A V Proto

AJR. American Journal of Roentgenology

|December 1, 1980

Summary

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Eggshell calcification in lymph nodes is typically seen in silicosis and coal worker's pneumoconiosis. This study presents amyloidosis and histoplasmosis as new causes, expanding the differential diagnosis for this imaging finding.

Area of Science:

Radiology
Pathology
Pulmonary Medicine

Background:

Peripheral lymph node calcification, known as "eggshell calcification," is a recognized finding.
This pattern is most commonly associated with occupational lung diseases like silicosis and coal-worker's pneumoconiosis.
Other reported causes include sarcoidosis, postirradiation Hodgkin disease, blastomycosis, and scleroderma.

Purpose of the Study:

To identify and present previously undescribed causes of eggshell calcification in lymph nodes.
To expand the differential diagnosis for this specific radiological pattern.
To list conditions that may mimic eggshell calcification.

Main Methods:

Literature review of known causes of eggshell calcification.
Presentation of two new cases demonstrating eggshell calcification.

Related Experiment Videos

Review of differential diagnoses for simulated eggshell calcification.

Main Results:

Amyloidosis and histoplasmosis are identified as two new causes of peripheral lymph node eggshell calcification.
A comprehensive list of disorders simulating eggshell calcification is provided.
The underlying mechanism for the eggshell calcification pattern remains unknown.

Conclusions:

The spectrum of conditions causing eggshell calcification in lymph nodes is broader than previously recognized.
Amyloidosis and histoplasmosis should be considered in the differential diagnosis of eggshell calcification.
Further research is needed to elucidate the pathogenesis of this calcification pattern.