Effects of prostaglandins on avidin induction in the chick oviduct

Effects of exogenous prostaglandins (PGs) on avidin synthesis in the oviduct were studied in immature diethylstilboestrol-treated chicks. Among eight tested PGs only PGF-2alpha was effective when injected directly into the oviduct, but intraperitoneal and intravenous administration also caused avidin induction. 1 ng of PGF-2alpha/100 g B.W. injected into the oviduct caused avidin synthesis. The effect of PGF-2alpha on avidin induction occurred as early as 3 hr after intraoviductal administration. This study provides an additional evidence for the hypothesis that PGF-2alpha may be involved in the mechanism of avidin induction in the chick oviduct.