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[Concentrated Totamin. Use in pediatric intensive care (author's transl)]
Insights
Simultaneous infusion of concentrated Totamin with serum glucose and electrolytes in pediatric patients leads to better nutrient utilization and nitrogen balance compared to separate infusions. This method enhances treatment efficacy in young patients.
Area of Science:
- Pediatric Nutrition
- Intravenous Therapy
- Metabolic Balance
Context:
- Evaluating nutritional support in pediatric patients.
- Assessing the efficacy of different intravenous infusion methods.
- Investigating nitrogen (N) balance and nutrient utilization.
Purpose:
- To compare the efficacy of simultaneous versus separated intravenous infusions of concentrated Totamin with serum glucose and electrolytes in pediatric patients.
- To determine the optimal method for improving nitrogen balance and nutrient utilization.
Summary:
- Thirty-two pediatric patients (2 days to 13 years) received venous infusions of concentrated Totamin.
- Group A (n=17) received separated infusions of Totamin followed by glucose/electrolytes; Group B (n=15) received simultaneous infusions.
- Simultaneous infusion demonstrated better Totamin utilization and a more favorable nitrogen balance, particularly at identical nitrogen intake levels.
Impact:
- Simultaneous infusion of Totamin with glucose and electrolytes is a more effective treatment strategy for pediatric patients.
- This method improves nutrient utilization and promotes a positive nitrogen balance.
- Findings provide insights for optimizing intravenous nutritional support in pediatric care.
Abstract:
Concentrated Totamin was administered by venous infusion in 32 pediatric patients, aged 2 days to 13 years. In 17 cases (group "A"), patients received Totamin by separated and isolated infusion, which was followed by serum glucose and electrolytes infusion. N intake was 0.17-0.32 g/kg/day (m = 0.23), caloric intake was 5-50 cal/kg/day (m = 25), duration of treatment was 5,17 days. In 15 cases (group "B") patients received Totamin, serum glucose and electrolytes simultaneously. N intake was 0.07-0.26 g/kg/day (m = 0.17), caloric intake was 20-72 cal/kg/day (m = 47), duration of treatment was 5 days. The N positive or equilibrate total positive balance ratio is identical in both the groups = 12/17 (70.6%) in group "A" and 10/15 (66.7%) in group "B". But in 11 patients (5 of group "A" and 6 of group "B") which received an identical N intake (0.20 g/kg/day) N balance was negative in 5 (A) and positive in 6 (B). Thus its appears that for an identical N intake, serum glucose infusion simultaneously with concentrated Totamin, is a more efficacious treatment than alternate infusion. Simultaneous infusion produces and better utilisation of Totamin and a N positive balance.