Related Experiment Video
Updated: Aug 11, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
Published on: January 2, 2013
Reaction of glutaraldehyde with human erytrocytes
Abstract:
The reaction of glutaraldehyde with human erythrocytes has been studied at pH values of 6.0, 7.2 and 8.0 at several glutaraldehyde concentrations, for different periods at 37 degrees C. Increasing pH and reagent concentration favours formation of cells resistant to osmotic and chemical (by n-butanol, saponin and sodium dodecyl sulfate (SDS)) hemolysis. Ultrasonic waves also have no effect upon these cells. Different behavior concerning the state of hemoglobin, K+ efflux, and swelling have also been observed, according to the pH of treatment. The results suggest that crosslinking involving hemoglobin molecules and components of the membrane (proteins, aminophospholipids) may be obtained in the reaction of human erythrocytes with glutaraldehyde.
Related Concept Videos
Lifecycle of Erythrocytes
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
Several distinctive characteristics distinguish glutathione conjugation from other phase II...

