Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Benign familial tremor treated with primidone.

M D O'Brien, A R Upton, P A Toseland

    British Medical Journal (Clinical Research Ed.)
    |January 17, 1981
    PubMed
    Summary

    Primidone effectively reduced benign familial tremor in a study of 20 patients. While some experienced side effects, 12 patients showed significant tremor reduction, indicating primidone

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vascular dementia: Problems with definition, nomenclature, and classification.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Vascular dementia: Problems with nomenclature, definition, and classification.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    The effect of age on the hydroxylation of amylobarbitone sodium in man.

    British journal of clinical pharmacology·2012
    Same author

    Metabolic adaptations to heat stress in growing cattle.

    Domestic animal endocrinology·2009
    Same author

    The importance of communication in secondary fragility fracture treatment and prevention.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006
    Same author

    Unusual presentations of neurological conditions: make your diagnoses.

    Journal of the Royal Society of Medicine·2005

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Benign familial tremor (BFT) is a neurological disorder characterized by involuntary shaking.
    • Current treatments for BFT have limited efficacy and significant side effects.
    • Primidone is an anticonvulsant medication primarily used for epilepsy management.

    Observation:

    • A patient with epilepsy experienced an unexpected reduction in benign familial tremor while on primidone.
    • This observation led to a prospective study investigating primidone's efficacy in BFT.
    • The study involved 20 patients diagnosed with benign familial tremor.

    Findings:

    • Primidone demonstrated significant efficacy in treating benign familial tremor, with 12 out of 20 patients achieving a good to dramatic response.
    • Phenylethylmalonamide, a metabolite of primidone, appears to be the primary mediator of the anti-tremor effect.
    • A notable proportion of patients (6/20) reported intolerance to primidone due to side effects like vertigo and nausea.

    Implications:

    • Primidone represents a highly effective therapeutic option for managing benign familial tremor.
    • Further research is warranted to optimize primidone dosage and minimize side effects in BFT patients.
    • The findings suggest a potential role for primidone and its metabolites in managing other tremor disorders.

    Related Experiment Videos