Related Experiment Videos
[Protective effect of ketotifen and disodium cromoglycate in bronchial challenge tests with allergens (author's
Insights
Ketotifen and disodium cromoglycate (DSCG) showed protective effects in children with allergic asthma. Both medications improved allergen tolerance, with ketotifen offering slightly better results against late-phase reactions.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Allergic bronchial asthma is a chronic respiratory condition affecting children.
- House dust mite and grass pollen are common allergens triggering asthma exacerbations.
- Evaluating the efficacy of anti-allergic medications is crucial for asthma management.
Purpose of the Study:
- To compare the protective effects of ketotifen and disodium cromoglycate (DSCG) in children with allergic bronchial asthma.
- To assess the impact of these medications on allergen tolerance and late-phase reactions.
Main Methods:
- A randomized, double-blind, cross-over study was conducted.
- 15 children with allergic asthma underwent bronchial challenge tests.
- Medication (ketotifen or DSCG) was administered for 4 days before repeat challenge.
Main Results:
- Seven out of 15 patients demonstrated improved allergen tolerance with ketotifen.
- Five out of 15 patients showed enhanced tolerance with DSCG.
- Protective effects against late reactions were observed in only 2 children with ketotifen and 1 with DSCG.
Conclusions:
- Both ketotifen and DSCG offer protective benefits in pediatric allergic asthma.
- Ketotifen appeared to provide a slightly greater improvement in allergen tolerance.
- Further research may be warranted to fully elucidate the mechanisms and long-term efficacy.
Abstract:
The protective effect of ketotifen and disodium cromoglycate (DSCG) was evaluated by a randomised double blind cross-over study in 15 children with allergic bronchial asthma. 13 children were allergic to house dust mite (Dermatophagoides pteronyssinus), two to grass pollen. After a positive bronchial challenge test ketotifen or DSCG was given for 4 days followed by bronchial challenge with increasing allergen concentrations. Seven patients showed better allergen tolerance after ketotifen, 5 after DSCG. Protective action against late reactions was found only in 2 children after ketotifen and one child after DSCG.