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Related Experiment Videos

Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey.

J E Morley, M J Raleigh, G L Brammer

    European Journal of Pharmacology
    |October 17, 1980
    PubMed
    Summary

    Altering serotonin systems in vervet monkeys affected thyroid hormone regulation. Repeated L-tryptophan or 5-HTP increased T3 and decreased TSH, suggesting complex interactions in hormonal control.

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    Area of Science:

    • Neuroendocrinology
    • Pharmacology
    • Thyroid Physiology

    Background:

    • The hypothalamus-pituitary-thyroid (HPT) axis is crucial for regulating metabolism and is influenced by various neurotransmitter systems.
    • Serotonin's role in modulating the HPT axis remains incompletely understood, with conflicting data from previous studies.

    Purpose of the Study:

    • To investigate the specific role of serotonin in regulating the HPT axis in vervet monkeys.
    • To differentiate between acute and repeated dose effects of serotonergic agents on thyroid hormone levels.

    Main Methods:

    • Vervet monkeys received acute or repeated doses of L-tryptophan and 5-hydroxytryptophan (5-HTP) to modulate serotonin levels.
    • Pharmacological agents targeting serotonin synthesis (p-chlorophenylalanine) and degradation (chlorgyline) were administered.

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  • Blood levels of serotonin, thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) were measured.

    • Main Results:

    • Acute L-tryptophan decreased the thyrotropin-releasing hormone (TRH)-induced TSH response but did not alter basal thyroid hormones.
    • Repeated administration of L-tryptophan or 5-HTP increased serotonin and plasma T3, while decreasing plasma TSH.
    • Inhibition of tryptophan hydroxylase did not affect HPT axis hormones, whereas monoamine oxidase inhibition increased TSH and T4 but decreased T3.

    Conclusions:

    • Serotonergic modulation has complex effects on the HPT axis, with repeated dosing showing more pronounced effects than acute administration.
    • Data suggest a potential role for central catecholaminergic systems, rather than solely serotonergic systems, in TRH release.
    • Peripheral serotonin may influence thyroid hormone levels, potentially through direct effects on the thyroid gland, leading to feedback regulation of TSH.