Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SCE frequency in malnourished mice.

P B Murthy, S G Srikantia

    Metabolism: Clinical and Experimental
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Protein deficiency significantly increases sister chromatid exchange (SCE) frequency in mice with protein energy malnutrition (PEM). Higher SCE levels correlate with lower protein intake, indicating a genotoxic effect of malnutrition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development and Validation of a Risk-Adapted Scoring Model for Metachronous Upper Tract Urothelial Carcinoma following Radical Cystectomy.

    The Journal of urology·2021
    Same author

    Clinical grading of lingual lesions in vitamin B-complex deficiency. 1980.

    The Indian journal of medical research·2013
    Same author

    Lack of genotoxicity of menthol in chromosome aberration and sister chromatid exchange assays using human lymphocytes in vitro.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Induction of sister chromatid exchanges in NIH 3T3 cells transformed by DNA from mice given cyclophosphamide.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods.

    Archives of toxicology·2010
    Same author

    Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone.

    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer·2002

    Area of Science:

    • Genetics
    • Nutrition Science
    • Toxicology

    Background:

    • Protein energy malnutrition (PEM) is a global health concern.
    • Nutritional deficiencies can impact cellular processes and DNA integrity.
    • Sister chromatid exchange (SCE) is a biomarker for genotoxicity.

    Purpose of the Study:

    • To investigate the impact of induced protein deficiency on SCE frequency.
    • To determine the relationship between protein intake levels and SCE rates in experimental models.

    Main Methods:

    • Experimental induction of protein energy malnutrition in mice.
    • Analysis of sister chromatid exchange (SCE) frequency in bone marrow cells.
    • Correlation analysis between protein content and SCE levels.

    Related Experiment Videos

    Main Results:

    • Malnourished mice showed significantly higher SCE frequencies compared to controls.
    • A dose-dependent relationship was observed: lower protein content led to increased SCE rates.
    • Bone marrow cells from malnourished subjects were particularly affected.

    Conclusions:

    • Induced protein deficiency exacerbates genotoxicity, as evidenced by elevated SCE.
    • Protein energy malnutrition poses a risk to genomic stability.
    • Dietary protein levels are critical in maintaining cellular integrity and preventing DNA damage.