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Updated: Aug 13, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Drug-induced disturbances of the coagulation system (author's transl)]
Abstract:
Side-effects of longterm therapy on the coagulation system become manifest either as hemorrhages or as an increased risk of thromboembolism. The most frequent drug-induced coagulation defect is thrombopathia. The most important drug-induced plasmatic coagulation disorders are caused by anti-coagulants and therefore predictable. In patients exposed to hemorrhage risk, non-steroidal antiphlogistics are not contraindicated since they entail inhibition of platelet aggregation and prolonged hemorrhage time. High doses of penicillin G and the semisynthetic penicillins can lead to hemorrhage in patients with renal insufficiency. Corticosteroids and contraceptives however tend to induce hypercoagulability.
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