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[Bioavailability of cimetidine after partial gastrectomy (author's transl)]
MMW, Munchener Medizinische Wochenschrift
|September 26, 1980
Summary
Cimetidine absorption is altered after gastrectomy. Patients with Billroth I or II surgery showed delayed peak plasma concentrations and increased bioavailability of cimetidine compared to healthy individuals.
Area of Science:
- Pharmacokinetics
- Gastrointestinal Surgery
- Drug Absorption
Context:
- Billroth I and Billroth II gastrectomies alter gastric anatomy and physiology.
- Understanding drug absorption post-gastrectomy is crucial for therapeutic management.
Purpose:
- To investigate the absorption characteristics of cimetidine in patients following Billroth I and Billroth II gastrectomies.
- To compare cimetidine absorption in post-gastrectomy patients with a control group.
Summary:
- Cimetidine absorption onset was similar across all groups.
- Peak plasma concentrations of cimetidine were delayed in Billroth I (18%) and significantly in Billroth II (42%) patients.
- Bioavailability (area under the curve) and duration of effective plasma concentrations were significantly increased in both gastrectomy groups.
Impact:
- Altered cimetidine pharmacokinetics post-gastrectomy necessitate potential dose or regimen adjustments.
- Findings contribute to optimizing drug therapy in patients with altered gastric anatomy.
- Highlights the importance of considering surgical history in drug efficacy and safety.