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Updated: Jul 13, 2026
10:09
Optimization of a Quantitative Micro-neutralization Assay
Published on: December 14, 2016
Neutralizing capacity and cost effectiveness of antacids
Annals of Internal Medicine
|February 1, 1981
Summary
Liquid antacids generally offer better acid neutralization and cost-effectiveness than tablets. Prescribing high-potency antacids is recommended for optimal therapy, considering taste and sodium content.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Physicians have numerous antacid options.
- Evaluating antacid efficacy and cost is crucial for patient care.
Purpose of the Study:
- To compare the acid-neutralizing capacity and cost-effectiveness of various antacids.
- To guide physicians in selecting optimal antacid preparations.
Main Methods:
- Tested commonly available liquid and tablet antacids for acid-neutralizing capacity.
- Calculated cost-effectiveness and tabulated monthly therapy costs.
Main Results:
- Liquid antacids generally outperform tablet formulations in acid neutralization and cost-effectiveness.
- High-potency liquid antacids (e.g., aluminum/magnesium hydroxide, calcium carbonate) show buffering capacities of 3-4.2 meq/mL, with monthly costs of $35-$74.
- Less effective liquid antacids had lower capacity (0.3-2.3 meq/mL) but higher costs ($78-$498).
Conclusions:
- Acid-neutralizing capacity is the primary driver of antacid therapy cost.
- High-potency antacids are more cost-effective.
- Physicians should also consider antacid taste and sodium content in their prescribing decisions.
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