[Development and drug correction of therapy resistance in chronic antihypertensive use]

In the course of a closely controlled ambulatory antihypertensive multicompetent therapy one part of the at first normotensively treated hypertensives reacts with a development of therapy-resistance due to volume expension. A correction of the development of the resistance can be achieved by directed and sufficiently doses parenteral and oral additional application of loop diuretics, aldosterone antagonists and peripheral vasodilators as a hypotensive intensive programme which can be performed in the outpatient department. With the help of observations of courses lasting several years in 16 patients with hypertension who were temporarily resistant to therapy and who could be regulated above all normotensively within the repeated antihypertensive intensive therapy phases, improved possibilities of a long-term effective performance of the therapy under the conditions of an outpatient department were shown.