Chronic myeloproliferative disorders: a quantitative assessment of platelet ultrastructure

In patients with chronic myeloproliferative disorders (MPD) and impaired in vitro platelet aggregation, a quantitative assessment of platelet ultrastructure showed reduced numbers of alpha granules and excessive dilation of the open canalicular systems. After 10 days of aspirin therapy, some abnormalities were significantly reduced. The implications of this finding are discussed.