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Sulfonylureas and platelet function.

L J Klaff, L Kernoff, A I Vinik

    The American Journal of Medicine
    |March 1, 1981
    PubMed
    Summary
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    Sulfonylurea drugs like gliclazide and glyburide normalize abnormal platelet aggregation in patients with diabetes mellitus. This improved platelet function may help prevent vascular disease, independent of glucose control.

    Area of Science:

    • Endocrinology
    • Hematology
    • Pharmacology

    Background:

    • Platelet hyperaggregability is observed in diabetes mellitus.
    • This abnormal platelet function is a potential contributor to vascular disease pathogenesis in diabetic patients.

    Purpose of the Study:

    • To investigate the effects of sulfonylurea agents (gliclazide and glyburide) on platelet aggregation in noninsulin-dependent diabetes mellitus.
    • To determine if observed changes in platelet function correlate with glycemic control.

    Main Methods:

    • Ten noninsulin-dependent diabetic subjects were treated with gliclazide or glyburide for six weeks.
    • Platelet aggregation was measured in response to adenosine diphosphate (ADP), epinephrine, and collagen.
    • Plasma glucose concentrations were monitored.

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    Main Results:

    • Platelets from diabetic patients showed abnormal sensitivity to ADP-induced aggregation compared to controls.
    • Treatment with both gliclazide and glyburide normalized ADP-induced platelet aggregation.
    • Glyburide significantly reduced aggregation in response to epinephrine and collagen.
    • Changes in platelet function did not correlate with improvements in plasma glucose levels.

    Conclusions:

    • Sulfonylurea treatment, specifically glyburide, can normalize abnormal platelet aggregation in diabetic patients.
    • The observed effects on platelet function appear to be independent of glycemic control.
    • These findings suggest a potential role for sulfonylureas in mitigating vascular disease risk in diabetes through modulation of platelet activity.