Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-DR patterns in pernicious anaemia.

B Ungar, J D Mathews, B D Tait

    British Medical Journal (Clinical Research Ed.)
    |March 7, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    General resource for ionospheric transient investigations (GRITI): An open-source code developed in support of the Dinsmore et al. (2021) results.

    MethodsX·2021
    Same author

    Safety, efficacy and pharmacokinetics of vedolizumab in patients with simultaneous exposure to an anti-tumour necrosis factor.

    Alimentary pharmacology & therapeutics·2018
    Same author

    Early drug and anti-infliximab antibody levels for prediction of primary nonresponse to infliximab therapy.

    Alimentary pharmacology & therapeutics·2017
    Same author

    Re-phrasing the question: A simple tool for evaluation of adherence to therapy in patients with inflammatory bowel disease.

    United European gastroenterology journal·2017
    Same author

    Dust mite induces multiple polar T cell axes in human skin.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
    Same author

    Letter: can addition of an immunomodulator really reverse antibody formation and loss of response in patients treated with adalimumab? Authors' reply.

    Alimentary pharmacology & therapeutics·2017

    Human Leukocyte Antigen (HLA)-DR antigen patterns are linked to Addisonian pernicious anemia. Specific HLA-DR combinations may influence susceptibility to pernicious anemia, with or without associated endocrine diseases.

    Area of Science:

    • Immunogenetics
    • Autoimmune Diseases

    Background:

    • Addisonian pernicious anemia is an autoimmune condition.
    • The role of Human Leukocyte Antigen (HLA) genes in autoimmune diseases is well-established.
    • Specific HLA-DR antigen associations have been observed in pernicious anemia.

    Purpose of the Study:

    • To investigate HLA-DR antigen patterns in patients with Addisonian pernicious anemia.
    • To compare HLA-DR antigen profiles between patients with and without associated endocrine diseases.
    • To explore potential interactions of HLA-DR antigens in disease susceptibility.

    Main Methods:

    • Studied HLA-DR antigen patterns in 66 patients with Addisonian pernicious anemia.
    • Subdivided patients into groups with (n=18) and without (n=48) associated endocrine disease.

    Related Experiment Videos

  • Compared patient groups to a control group (n=120) using statistical analysis.

    • Main Results:

    • All 66 patients showed increased HLA-DR2 and DR4, and decreased DR3 compared to controls.
    • Significant differences in HLA-DR patterns and combinations were found between endocrine and non-endocrine subgroups.
    • The endocrine subgroup had increased HLA-DR3/DR4, while the non-endocrine subgroup showed increased HLA-DR2/DR4 and DR4/DR5.

    Conclusions:

    • HLA-DR antigens or linked genes may influence susceptibility to pernicious anemia and/or endocrine disease.
    • Specific HLA-DR interactions (e.g., HLA-DR2/DR4, DR4/DR5) may predispose to pernicious anemia without endocrine disease.
    • HLA-DR3/DR4 interactions may predispose to pernicious anemia associated with endocrine disease.