Effects of venesection on cerebral function in chronic lung disease

Area of Science:

• Neurology
• Hematology
• Pulmonology

Background:

• Polycythemia secondary to chronic obstructive pulmonary disease (COPD) can increase blood viscosity.
• Increased blood viscosity may impair regional cerebral blood flow (rCBF) and cognitive function.

Purpose of the Study:

• To investigate the effects of venesection on rCBF and neuropsychological function in patients with secondary polycythemia and COPD.

Main Methods:

• rCBF measurements and neuropsychological tests were performed before and after venesection in 6 patients.
• Venesection aimed to reduce hematocrit and blood viscosity.

Main Results:

• Venesection led to decreased blood viscosity and hematocrit.
• Significant improvements in rCBF, particularly in the left cerebral hemisphere, were observed.
• Patients showed significant enhancements in sensory and mental function.

Conclusions:

• Venesection is a viable treatment to improve cerebral perfusion and cognitive function in polycythemia secondary to COPD.
• Cerebral blood flow and function are closely linked to blood viscosity.