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Related Experiment Videos

Angiolymphoid hyperplasia with eosinophilia simulating lymphadenopathy.

D H Wright, N R Padley, M A Judd

    Histopathology
    |March 1, 1981
    PubMed
    Summary

    Angiolymphoid hyperplasia with eosinophilia (AHE) can mimic lymphadenopathy with recurrent inguinal swellings. Electron microscopy and immunohistochemistry revealed characteristic endothelial cell changes and ruled out histiocytic origins.

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    Area of Science:

    • Vascular Pathology
    • Immunohistochemistry
    • Electron Microscopy

    Background:

    • Angiolymphoid hyperplasia with eosinophilia (AHE) is a rare condition.
    • AHE typically presents as cutaneous papules or nodules, often on the head and neck.
    • Inguinal swellings simulating lymphadenopathy are an unusual presentation of AHE.

    Observation:

    • A case of AHE with eosinophilia presented with recurrent inguinal swellings.
    • Light microscopy, electron microscopy, and immunohistochemistry were utilized for tissue examination.
    • Electron microscopy identified atypical endothelial cells with cytoplasmic filaments and bizarre Weibel-Palade bodies.

    Findings:

    • Factor VIII related antigen was positive in a subset of atypical endothelial cells.
    • Absence of lysozyme and alpha 1 antitrypsin staining argued against a histiocytic origin.

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  • Lymphoid and plasma cell proliferation showed a polytypic immunoglobulin staining pattern.
  • An unusual reticular IgE staining pattern was noted in lymphoid follicles.

    • Implications:

    • This case highlights an atypical presentation of AHE, emphasizing the importance of considering AHE in the differential diagnosis of inguinal swellings.
    • The findings support the endothelial cell origin of AHE and provide further insight into its pathogenesis.
    • Understanding the immunophenotype of AHE is crucial for accurate diagnosis and management.