Neuro-histological reactions following tooth extractions

The neuro-histological reactions after tooth extraction were investigated in the extraction alveolus, the mandibular nerve and the trigeminal ganglion. In the ganglion, nerve cell bodies showing signs of retrograde reaction (chromatolysis and nuclear displacement) were seen 12 h after extraction. Maximal number of reacting cells were registered in the first postoperative week. Three weeks after extraction the number of reacting cells were at a normal low level. In the mandibular nerve no signs of axon degeneration could be demonstrated. In the alveolus, initial traumatic axon degeneration was followed by regeneration 2 days after extraction. Within the first postoperative week the alveolus was filled with connective tissue, in which many long thin axons were seen. Cancellous bone then filled the alveolus; the axons were thereby gathered - concentrated - into fascicles in the central part, with a direction towards the limbus. However, this was only passed by very few axons. Four months after extraction signs of axon degeneration were seen, and 2 months later the myelin sheaths also displayed degenerative signs. Ten months after extraction a minor area of connective tissue with a content of few axons and vessels was found at the bottom of the former alveolus. The histological appearance was of a small traumatic neuroma.