Antibacterial activity of five cephalosporins

The in vitro susceptibilities of 7 commonly isolated species of bacteria to cephalothin, cefoxitin, and 3 new cephalosporins--cephamandole, cefuroxime, and cefoperazone--were studied using an agar dilution method. Cephalothin and cephamandole were the most active agents against staphylococci. Against members of the Enterobacteriaceae all the newer agents were more active than cephalothin; however, important individual differences emerged. Only cefoperazone had significant activity against Pseudomonas aeruginosa.