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Cyclophosphamide induced nail pigmentation.

P C Shah, K R Rao, A R Patel

    The British Journal of Dermatology
    |June 1, 1978
    PubMed
    Summary
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    Cyclophosphamide treatment can cause black nail pigmentation, a side effect observed in multiple patients. This nail discoloration resolves after discontinuing the chemotherapy drug.

    Area of Science:

    • Oncology
    • Dermatology
    • Pharmacology

    Background:

    • Cyclophosphamide is a widely used chemotherapy agent.
    • Adverse drug reactions require thorough documentation and understanding.

    Observation:

    • This study reports five new cases of black nail pigmentation associated with cyclophosphamide therapy.
    • An additional eleven cases from existing literature are reviewed.

    Findings:

    • Nail pigmentation begins at the proximal nail bed and moves distally.
    • Pigmentation resolves in a similar pattern after cyclophosphamide withdrawal.
    • The onset of nail changes is unrelated to the underlying condition treated with cyclophosphamide.

    Implications:

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  • Clinicians should be aware of this potential side effect of cyclophosphamide.
  • Monitoring nail changes may be beneficial during cyclophosphamide treatment.
  • Further research is needed to elucidate the mechanism of cyclophosphamide-induced nail pigmentation.