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Cimetidine and parenteral nutrition
JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1981
Summary
Continuous intravenous infusion of cimetidine (CT) mixed with hyperalimentation solutions appears safe for patients needing gastric acid control. Serum CT levels remained within a safe range, showing no signs of toxicity in this initial study.
Area of Science:
- Pharmacology
- Gastroenterology
- Clinical Pharmacy
Background:
- Patients on hyperalimentation often require treatment for gastric hypersecretory conditions.
- Cimetidine (CT) is used to manage these conditions.
- Investigating safe drug administration routes is crucial for patient care.
Purpose of the Study:
- To evaluate the safety and pharmacokinetic profile of administering cimetidine (CT) via continuous intravenous infusion mixed with hyperalimentation solutions.
- To determine serum concentrations of CT under this administration method.
Main Methods:
- Four patients receiving hyperalimentation were administered a mixture containing cimetidine (CT).
- Continuous intravenous infusion of CT at rates of 38 to 56.3 mg/hr.
- Serial blood sampling was performed to measure steady-state serum CT concentrations (C88).
Main Results:
- Average steady-state serum CT concentrations ranged from 0.6 to 1.0 microgram/ml.
- These levels are comparable to those seen with long-term oral CT administration.
- Observed CT levels were below those associated with central nervous system toxicity, and no renal toxicity was detected.
Conclusions:
- Continuous intravenous infusion of cimetidine (CT) in hyperalimentation solutions is a potentially safe method for drug delivery.
- Pharmacokinetic parameters were consistent with existing literature.
- Further studies are warranted to confirm efficacy.