An analysis of visual object reversal learning in the marmoset after amphetamine and haloperidol

The effect of amphetamine and haloperidol pretreatment on visual object reversal learning was assessed in the marmoset. Amphetamine induced perseverative responding demonstrated by high reversal learning scores and worse than chance performance in the early stages of reversal. This perseverative responding was prevented by pretreatment with haloperidol. Haloperidol, either alone or in conjunction with amphetamine caused a mild, non-perseverative impairment on reversal learning only.