Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetal pepsinogens in human amniotic fluid.

W M Liebman, I M Samloff

    Biology of the Neonate
    |January 1, 1978
    PubMed
    Summary

    Group I pepsinogen (Pg I) is found in all human amniotic fluid samples, while Group II pepsinogen (Pg II) appears after 32 weeks gestation. This sequential presence suggests a fetal origin and potential marker for fetal maturity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Implications of serum pepsinogen I in early endoscopic diagnosis of gastric cancer and dysplasia. Helsinki Gastritis Study Group.

    Scandinavian journal of gastroenterology·2000
    Same author

    Gastric cancer and premalignant lesions in atrophic gastritis: a controlled trial on the effect of supplementation with alpha-tocopherol and beta-carotene. The Helsinki Gastritis Study Group.

    Scandinavian journal of gastroenterology·1998
    Same author

    Gastric acidity in older adults.

    JAMA·1997
    Same author

    Helicobacter pylori antibodies in relation to precancerous gastric lesions in a high-risk Chinese population.

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·1996
    Same author

    Rate of Helicobacter pylori acquisition among Finnish adults: a fifteen year follow-up.

    Scandinavian journal of gastroenterology·1996
    Same author

    Serum pepsinogen C: a useful marker of Helicobacter pylori eradication?

    Journal of clinical laboratory analysis·1996

    Area of Science:

    • Perinatal Medicine
    • Biochemistry
    • Fetal Development

    Background:

    • Pepsinogens (Pg) are precursors to pepsin, crucial for digestion.
    • Understanding fetal development of the gastric system is vital for assessing maturity.
    • Group I (Pg I) and Group II (Pg II) pepsinogens have distinct characteristics.

    Purpose of the Study:

    • To determine the presence and pattern of Group I and Group II pepsinogens in human amniotic fluid.
    • To investigate the potential of these pepsinogens as markers of fetal maturity.

    Main Methods:

    • Analysis of 59 human amniotic fluid samples.
    • Samples collected from 11 to 40 weeks of gestation.
    • Detection of Group I (Pg I) and Group II (Pg II) pepsinogens.

    Main Results:

    • Group I pepsinogen (Pg I) was detected in all samples.
    • Group II pepsinogen (Pg II) was present only in samples from 32 weeks gestation onwards.
    • No differential pattern observed in Pg I fractions, with the first fraction absent.

    Conclusions:

    • The sequential appearance of Pg I and Pg II indicates a fetal origin.
    • Pg I synthesis by the fetal gastric mucosa may precede Pg II synthesis.
    • Pepsinogen presence and patterns may serve as potential indicators of fetal maturity.

    Related Experiment Videos