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[Antibiotic behavior of Ps. aeruginosa strains isolated from various types of clinical material]
Abstract:
Altogether 158 strains of P. aeruginosa isolated from the material of open and close cavities and blood of patients with bronchopulmonary diseases were studied. It was found that the majority of the virulent (92.6 per cent) and avirulent (70.3 per cent) cultures were characterized by multiple resistance to tetracycline, streptomycin, monomycin, kanamycin, levomycetin and polymyxin B with preserved sensitivity to gentamicin and carbenicillin. The source of the P. aeruginosa isolation had a significant influence on its relation to the effect of antibiotics: the highest number of the resistant cultures was isolated from the blood. No differences in the antibiotic effect on P. aeruginosa depending on the serotype were observed. No differences in the antibiotic effect on P. aeruginosa depending on the serotype were observed. Virulent cultures of P. aeruginosa typed with group agglutinating sera and isolated from the material of the open and close cavities were characterized by a higher resistance level to tetracycline, kanamycin, monomycin and levomycetin than the virulent not-typed strains.
Insights
Most Pseudomonas aeruginosa strains from patients with lung diseases show resistance to common antibiotics but remain sensitive to gentamicin. Resistance varied by isolation source, with blood samples yielding the most resistant cultures.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Pseudomonas aeruginosa is an opportunistic pathogen frequently causing hospital-acquired infections.
- Antibiotic resistance in P. aeruginosa poses a significant challenge in treating bronchopulmonary diseases.
Purpose of the Study:
- To investigate the antibiotic resistance patterns of P. aeruginosa strains isolated from patients with bronchopulmonary diseases.
- To determine the influence of isolation source and serotype on antibiotic resistance.
Main Methods:
- Studied 158 strains of P. aeruginosa from various clinical sources (cavities, blood).
- Assessed antibiotic susceptibility to multiple drugs including tetracycline, streptomycin, gentamicin, and others.
- Compared resistance levels between virulent and avirulent strains, and typed vs. untyped strains.
Main Results:
- A high prevalence of multidrug resistance was observed in both virulent (92.6%) and avirulent (70.3%) P. aeruginosa strains.
- Gentamicin and carbenicillin showed preserved sensitivity, while resistance was high to tetracycline, streptomycin, monomycin, kanamycin, levomycetin, and polymyxin B.
- P. aeruginosa strains isolated from blood exhibited the highest resistance rates.
- Virulent, typed strains from cavities showed higher resistance to certain antibiotics compared to untyped strains.
Conclusions:
- P. aeruginosa in bronchopulmonary infections displays significant multidrug resistance, necessitating careful antibiotic selection.
- Gentamicin and carbenicillin remain potential treatment options, but emerging resistance patterns require continuous monitoring.
- Isolation source significantly impacts P. aeruginosa antibiotic resistance profiles.