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[Hemodynamic effects of percutaneous trinitrin].

A Page, L Ledain, P Gateau

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |April 1, 1981
    PubMed
    Summary
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    Nitroglycerin (NG) ointment effectively reduced right atrial pressure and pulmonary artery diastolic pressure in patients, offering a long duration of action suitable for nocturnal angina treatment.

    Area of Science:

    • Cardiovascular Pharmacology
    • Hemodynamics
    • Nitrate Therapeutics

    Context:

    • Nitroglycerin (NG) is a vasodilator used to treat cardiovascular conditions.
    • Understanding the hemodynamic effects of topical NG formulations is crucial for optimizing patient care.
    • Congestive cardiac failure (CCF) patients may have altered responses to vasodilators.

    Purpose:

    • To evaluate the hemodynamic effects of a novel nitroglycerin (NG) ointment formulation.
    • To assess the duration of action and local tolerance of topical NG.
    • To determine the efficacy of NG ointment in patients with congestive cardiac failure.

    Summary:

    • Topical NG ointment administration led to significant reductions in right atrial pressure (RAP) and pulmonary artery diastolic pressure (PADP).

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  • Hemodynamic changes, including decreased mean arterial pressure (MAP), were observed with a slight decrease in heart rate (HR).
  • Cardiac index (CI) remained stable, suggesting peripheral arterial resistance did not significantly change.

    • Impact:

    • Nitroglycerin ointment demonstrates a prolonged duration of action, with significant PADP reduction persisting for up to 5 hours.
    • This extended efficacy makes NG ointment a promising option for managing nocturnal angina.
    • The formulation exhibited good local tolerance and did not cause excessive hypotension.