Jove
Visualize
Contact Us

Related Experiment Videos

Comparison of simple screening tests for fat malabsorption.

P S West, G E Levin, G E Griffin

    British Medical Journal (Clinical Research Ed.)
    |May 9, 1981
    PubMed
    Summary

    A 14CO2 breath test effectively screens for fat malabsorption, outperforming serum tests. This simple breath analysis offers a convenient alternative to traditional fecal fat collection methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of exercise training in the cold on cerebral blood flow and cerebrovascular function in young healthy individuals.

    Autonomic neuroscience : basic & clinical·2022
    Same author

    Globalization of Traditional Chinese Medicine: what are the issues for ensuring evidence-based diagnosis and therapy?

    Journal of internal medicine·2019
    Same author

    Extra-genital transmission of syphilis; case report.

    Military surgeon·2010
    Same author

    Plasma volume, usable volume (thiocyanate) and total proteinemia in normal adults.

    Anales de cirugia·2010
    Same author

    The absorption of blood from the perit oneal cavity of the dog.

    Federation proceedings·2010
    Same author

    The increasing hospital disease burden of haemochromatosis in England.

    Alimentary pharmacology & therapeutics·2009
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Gastroenterology
    • Diagnostic Medicine
    • Biochemistry

    Background:

    • Fat malabsorption is a condition affecting nutrient absorption.
    • Accurate screening methods are crucial for timely diagnosis and management.
    • Current diagnostic methods can be invasive or inconvenient.

    Purpose of the Study:

    • To evaluate three non-invasive tests for screening fat malabsorption.
    • To compare the efficacy of serum optical density, serum triglyceride levels, and 14CO2 breath excretion.
    • To determine the most reliable and convenient screening procedure.

    Main Methods:

    • Administered a fat meal containing glycerol tri[1-14C]oleate to 52 patients and 8 controls.
    • Measured serum optical density and triglyceride concentration.
    • Assessed 14CO2 breath excretion over 7-8 hours.
    • Compared breath test results with 3-day fecal fat excretion measurements.

    Main Results:

    • Serum optical density and triglyceride tests showed poor discrimination between normal and malabsorptive states.
    • The 14CO2 breath excretion test demonstrated high accuracy with no false negatives and only 7% false positives.
    • Breath analysis proved to be a simple and convenient screening method.

    Conclusions:

    • 14CO2 breath excretion is a highly effective and accurate screening tool for fat malabsorption.
    • Breath analysis offers a practical and convenient alternative to fecal fat testing.
    • This method simplifies the diagnostic process for fat malabsorption.

    Related Experiment Videos