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Related Experiment Videos

Selenium supplementation in total parenteral nutrition.

A M van Rij, J M McKenzie, C D Thomson

    JPEN. Journal of Parenteral and Enteral Nutrition
    |March 1, 1981
    PubMed
    Summary

    Selenium (Se) supplements, including selenomethionine and sodium selenite, are safe and effective for patients with very low plasma Se levels. Selenomethionine showed greater retention, but plasma Se levels are the best indicator of supplement response.

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    Area of Science:

    • Biochemistry
    • Nutritional Science
    • Clinical Medicine

    Background:

    • Patients receiving total parenteral nutrition (TPN) are at risk for developing very low plasma selenium (Se) levels.
    • Monitoring and supplementing Se is crucial for these at-risk individuals.

    Observation:

    • Four adult patients with plasma Se levels ≤1.5 microgram/100 ml received oral or intravenous Se supplements (selenomethionine or sodium selenite).
    • Urinary excretion and plasma Se responses varied between the two compounds and administration routes.

    Findings:

    • Selenomethionine demonstrated greater Se retention compared to sodium selenite.
    • Se incorporation into erythrocytes and glutathione peroxidase activity was unpredictable and delayed, making it an unreliable indicator of supplement response.

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  • No adverse effects were observed from Se supplementation.

    • Implications:

    • Se supplementation is recommended for patients at high risk of Se deficiency, particularly those on TPN.
    • Plasma Se levels serve as the most reliable biomarker for monitoring the efficacy of Se supplementation.
    • Further research may explore optimal Se forms and delivery methods for improved bioavailability and predictable incorporation into cellular components.