[Effect of diphenylhydantoin (DPH) on the EEG curves in epileptics]

Clinical and electroencephalographic investigations were performed and the diphenylhydantoin level was determined in the serum in a homogenous group of 32 young males aged 20-22 years staying in hospital. The spectrophotometric determination of the drug was found to be useful. The effect of therapeutic DPH level on regression of abnormal EEG tracings was demonstrated to be statistically significant. Absence of improvement or exacerbation of EEG changes should arouse the suspicion that the levels of 10 to 20 micrograms/ml of DPH in the serum has not been attained or has been exceeded.