Studies on liver toxicants: influence of bromobenzene on hepatic microsomal enzymes in mice

The effect of acute bromobenzene intoxication on drug-metabolizing liver enzymes was studied. After an oral dose of 3000 mg/kg body weight of bromobenzene, the glucuronyltransferases I and II were increased, indicating an enzyme activation by this organic solvent via membrane irritation. The mixed-function oxidases were inhibited with the exception of the ketamine N-demethylase. Microsomal lipoperoxidation was reduced whilst H2O2 formation was unchanged.