Experimental intra-arterial infusion of Microencapsulated Mitomycin C into pelvic organs

Area of Science:

• Oncology
• Pharmacology
• Interventional Radiology

Background:

• Transcatheter embolisation is a minimally invasive procedure.
• Mitomycin C is an anticancer agent with potential applications in embolisation.
• Drug delivery and retention are critical for therapeutic efficacy.

Purpose of the Study:

• To evaluate the laboratory use of ethylcellulose microencapsulated Mitomycin C (MMC-m.c.) for transcatheter embolisation.
• To examine the distribution of Mitomycin C in plasma and pelvic tissues following intra-arterial infusion in a canine model.
• To assess the retention and biological potential of encapsulated Mitomycin C in target tissues.

Main Methods:

• Laboratory preparation of Mitomycin C encased in ethylcellulose microcapsules.
• Intra-arterial infusion of MMC-m.c. into the pelvic organs of dogs via arterial catheterisation.
• Analysis of Mitomycin C levels in plasma and tissue samples at various time points.

Main Results:

• Significantly lower circulating Mitomycin C levels were observed in the MMC-m.c. group compared to the non-encapsulated Mitomycin C group.
• Biological potential of Mitomycin C was retained for extended periods in pelvic organs after MMC-m.c. infusion.
• Mitomycin C was undetectable in tissues of the non-encapsulated group 4 hours post-infusion.

Conclusions:

• Ethylcellulose microencapsulation of Mitomycin C is a promising strategy for transcatheter embolisation.
• This formulation enhances localized drug retention in target tissues while minimizing systemic exposure.
• Microencapsulated Mitomycin C demonstrates sustained biological activity, suggesting improved therapeutic outcomes in embolisation procedures.