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Summary
A massive plasma cell infiltration caused hypothyroidism and struma in a 70-year-old woman. This condition met the histologic criteria for plasma cell granuloma, highlighting a rare cause of thyroid dysfunction.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Plasma cell granuloma is a rare, benign condition characterized by a localized proliferation of plasma cells.
- Thyroid dysfunction, including hypothyroidism, can arise from various causes, often related to autoimmune processes or nodules.
Observation:
- A 70-year-old female patient presented with clinical signs of both hypothyroidism and struma (enlarged thyroid gland).
Findings:
- Histologic examination revealed a massive polyclonal plasma cell infiltration within the thyroid tissue.
- The observed infiltration fulfilled the established diagnostic criteria for plasma cell granuloma.
Implications:
- This case underscores that plasma cell granuloma can manifest as a cause of hypothyroidism and struma.
- The findings emphasize the importance of considering rare infiltrative diseases in the differential diagnosis of thyroid enlargement and dysfunction.