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Prolatin secreting pituitary adenomas
International Advances in Surgical Oncology
|January 1, 1981
Summary
Surgical removal of prolactin-secreting pituitary adenomas is effective, especially in women with non-invasive tumors and lower prolactin levels. Early diagnosis is crucial to improve surgical outcomes for both sexes.
Area of Science:
- Endocrinology
- Neurosurgery
- Oncology
Background:
- Prolactin-secreting pituitary adenomas are the most common pituitary tumors, affecting women more than men.
- These tumors often cause gonadal dysfunction as the primary symptom.
- Invasive adenomas present significant treatment challenges.
Purpose of the Study:
- To evaluate the efficacy of transsphenoidal surgery for prolactin-secreting pituitary adenomas.
- To identify factors influencing surgical success rates.
- To emphasize the need for early detection of these tumors.
Main Methods:
- Selective adenoma removal via transsphenoidal surgery.
- Treatment of 40 females and 10 males with prolactinomas.
- Analysis of preoperative prolactin levels and tumor invasiveness.
Main Results:
- Surgical correction of hyperprolactinemia achieved in 75% of women with preoperative prolactin ≤ 200 ng/ml.
- Successful normalization of prolactin in 71% of women with non-invasive adenomas.
- 50% of men with invasive adenomas achieved normalized prolactin levels post-surgery.
Conclusions:
- Transsphenoidal surgery is an effective treatment for prolactin-secreting pituitary adenomas, particularly in women with non-invasive tumors and lower prolactin levels.
- Men with invasive adenomas have poorer surgical outcomes.
- Early diagnosis and intervention are critical to prevent tumor invasiveness and improve treatment success.