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Reproductive function during fasting in men.

A Klibanski, I Z Beitins, T Badger

    The Journal of Clinical Endocrinology and Metabolism
    |August 1, 1981
    PubMed
    Summary
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    Short-term fasting in obese men impacts reproductive hormones. Follicle-stimulating hormone (FSH) levels and response to gonadotropin-releasing hormone (GnRH) decrease, while testosterone drops and urinary LH/FSH increase.

    Area of Science:

    • Endocrinology
    • Reproductive Physiology
    • Human Metabolism

    Background:

    • Obesity is associated with hormonal imbalances.
    • Fasting can significantly alter metabolic and endocrine functions.
    • Understanding reproductive health during caloric restriction is crucial.

    Purpose of the Study:

    • To investigate the effects of a short-term total fast on reproductive function in obese men.
    • To assess hormonal changes, including gonadotropins and testosterone, during fasting and refeeding.

    Main Methods:

    • An 18-day study involving obese men (20-74% over ideal body weight).
    • Included a 3-day control, 10-day total fast, and 5-day refeeding period.
    • Measured serum and urinary levels of LH, FSH, and testosterone, along with GnRH stimulation tests.

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    Main Results:

    • Significant decrease in serum FSH and blunted FSH response to GnRH stimulation.
    • Serum testosterone levels decreased significantly by day 9 of fasting.
    • Increased 24-hour urinary excretion of both LH and FSH during fasting, with prolonged elevation for LH post-refeeding.

    Conclusions:

    • Short-term fasting in obese men leads to decreased serum FSH and blunted pituitary responsiveness to GnRH.
    • Fasting reduces serum testosterone levels and increases urinary excretion of LH and FSH.
    • Reproductive hormone regulation is notably affected by short-term caloric restriction in this population.