Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of testosterone enanthate on testis size.

A Palacios, R D McClure, A Campfield

    The Journal of Urology
    |July 1, 1981
    PubMed
    Summary

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Entanglement and electronic coherence in attosecond molecular photoionization.

    Nature·2026
    Same author

    Modification and validation of the Bluebelle Wound Healing Questionnaire (WHQ) for assessing surgical site infection in wounds healing by secondary intention.

    Journal of tissue viability·2025
    Same author

    Proper Orthogonal Decomposition Methods for the Analysis of Real-Time Data: Exploring Peak Clustering in a Secondhand Smoke Exposure Intervention.

    Journal of computational science·2023
    Same author

    Controlling Fragmentation of the Acetylene Cation in the Vacuum Ultraviolet via Transient Molecular Alignment.

    The journal of physical chemistry letters·2022
    Same author

    Attosecond photoionisation time delays reveal the anisotropy of the molecular potential in the recoil frame.

    Nature communications·2022
    Same author

    Attosecond timing of electron emission from a molecular shape resonance.

    Science advances·2020

    Testosterone enanthate injections reduced testicular volume and sperm count in men, showing potential as a male contraceptive. However, sperm suppression was not immediate, and testicular volume returned to normal after discontinuing treatment.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Pharmacology

    Background:

    • Hormonal male contraception is an area of active research.
    • Testosterone therapy has been investigated for its effects on spermatogenesis.

    Purpose of the Study:

    • To evaluate testosterone enanthate as a potential male contraceptive agent.
    • To assess the impact of testosterone enanthate on testicular volume and sperm production.

    Main Methods:

    • 39 healthy men received intramuscular testosterone enanthate (200 mg).
    • Dosing regimens included weekly or bimonthly injections.
    • Testicular volume and sperm counts were monitored throughout the study.

    Main Results:

    • Weekly or bimonthly testosterone enanthate treatment for 4 months decreased testicular volume by 16.5-19.0%.
    Keywords:
    AndrogensBiologyClinical ResearchContraceptionContraception ResearchContraceptive AgentsContraceptive Agents, MaleEndocrine SystemEstradiolExaminations And DiagnosesFamily PlanningFollicle Stimulating HormoneGenitaliaGenitalia, MaleHormonesHuman VolunteersLaboratory Examinations And DiagnosesLaboratory ProceduresLuteinizing HormoneMale ContraceptionPhysiologyResearch MethodologyReversibilitySperm Count--analysisSpermatogenesis Blocking AgentsTestis--side effectsTestosterone--administraction and dosageUrogenital System

    Related Experiment Videos

  • Decreased testicular volume correlated with reduced sperm counts.
  • Additional weekly injections suppressed sperm counts to <5 million/cc in 13/17 men, with further testicular volume reduction.
  • Less frequent injections led to testicular volume recovery.

    • Conclusions:

    • Testosterone enanthate can suppress spermatogenesis and reduce testicular volume in men.
    • The effectiveness as a contraceptive agent depends on achieving and maintaining low sperm counts.
    • Reversibility of testicular volume was observed after treatment cessation.