Ceruloplasmin and liver diamine oxidase in guinea pig after industrial emulsifiers application

Plasma ceruloplasmin and liver diamine oxidase were measured in guinea pigs pretreated with industrial emulsifiers (long chain aliphatic amines combined with ethylene oxides). Emulsifiers produced biphasic changes in ceruloplasmin activity. An increase observed the 1st and 3rd day was followed by a drop at the 7th day. Diamine oxidase was diminished markedly at 1st day. The inflammation of liver followed by its impairment produced by industrial emulsifiers is discussed as a cause of these metabolic changes.