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[Brucella keratoconjunctivitis].

M M van Rooyen

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    A veterinarian experienced severe eye inflammation after accidental Brucella abortus vaccine exposure. Despite treatment, complications like corneal abscess and panophthalmitis led to eye enucleation, highlighting Brucella keratoconjunctivitis risks.

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    Area of Science:

    • Ophthalmology
    • Veterinary Medicine
    • Infectious Diseases

    Background:

    • Brucella species are zoonotic pathogens causing brucellosis.
    • Ocular involvement in brucellosis can range from mild conjunctivitis to severe sight-threatening conditions.

    Observation:

    • A veterinarian developed unilateral keratoconjunctivitis after accidental ocular exposure to Brucella abortus vaccine.
    • The condition progressed to involve the second eye, with subsequent development of corneal abscess, uveitis, and cataract.
    • Recurrent episodes of keratoconjunctivitis occurred upon further handling of the vaccine, leading to panophthalmitis and enucleation.

    Findings:

    • Initial Brucella tests were negative, but serological titers for Brucella abortus and Brucella melitensis rose significantly over two months.

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  • Standard systemic and local treatments were ineffective in resolving the ocular inflammation and complications.
  • The clinical presentation of Brucella keratoconjunctivitis was challenging to distinguish from viral etiologies.

    • Implications:

    • This case underscores the potential for severe ocular morbidity following accidental exposure to Brucella vaccines.
    • It highlights the importance of considering Brucella infection in the differential diagnosis of severe keratoconjunctivitis, especially in individuals with occupational exposure.
    • Enhanced preventive measures and prompt, specific diagnostic approaches are crucial for managing such occupational hazards.