Oxidative deamination of 14C putrescine in mouse tissues in vivo

Oxidative deamination of 14C putrescine was examined in vivo in mice. Exogenous putrescine is catabolized rapidly; 2.5 min after i.v. putrescine infection, its main oxidative metabolites, namely GABA and an unidentified compound were detected in all tissues tested; inhibition of DAO activity by aminoguanidine strongly suppressed formation of both products.