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Zinc absorption in the rat.

M J Jackson, D A Jones, R H Edwards

    The British Journal of Nutrition
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals two distinct zinc absorption mechanisms in rats. One adapts to low dietary zinc, while the other maintains absorption proportionally in normal zinc status, suggesting excretion regulates zinc homeostasis.

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    Area of Science:

    • Nutritional Science
    • Gastroenterology
    • Physiology

    Background:

    • Zinc is an essential trace element crucial for numerous biological functions.
    • Understanding zinc absorption mechanisms is vital for managing nutritional status and related disorders.

    Purpose of the Study:

    • To develop and utilize a novel method for studying zinc absorption in rats.
    • To elucidate the distinct mechanisms controlling zinc absorption and their regulation.

    Main Methods:

    • Developed a technique using radioactive zinc (Zn) to quantify intestinal mucosal binding and carcass absorption over time.
    • Administered Zn via stomach tube to rats with varying dietary zinc levels.

    Main Results:

    • Identified two zinc absorption pathways: one responsive to dietary zinc levels and another independent of it.

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  • The carcass absorption proportion varied with zinc status, but intestinal wall zinc did not, supporting two mechanisms.
  • A low dietary zinc content induced one mechanism, while the other, predominant in normal zinc status, showed absorption proportional to intake.

    • Conclusions:

    • Zinc homeostasis in rats under normal dietary conditions is primarily maintained through regulated zinc excretion.
    • A second, inducible zinc absorption mechanism becomes active only at very low dietary zinc concentrations (below 0.24 µMOL/g diet).