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Updated: Aug 10, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Puff volume increases when low-nicotine cigarettes are smoked
Abstract:
Variables of smoking were measured when subjects smoked the first cigarette of the day after an eight- to 10-hour period of abstinence. The cigarettes smoked had high, medium, or low nicotine yields but the tar and carbon monoxide yields, taste, and draw characteristics remained constant. The number of puffs and interval between puffs did not differ between nicotine doses. The smokers took larger puffs, however, when smoking cigarettes delivering lower nicotine yields than their normal brands. This change in the size of puff must be attributed to the change in nicotine yield since all other characteristics of the cigarettes remained constant. Thus encouraging the smoking of low-nicotine cigarettes may increase exposure to combustion products and not appreciably decrease exposure to nicotine, since the smokers increased the size of their puffs in response to the decreased nicotine yield.
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