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Updated: Aug 12, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
Published on: April 16, 2012
[Immunologic deficiency linked to aging. Role of monocytes]
Abstract:
The capacity of mononuclear cells from individuals over 70 years of age to mount a primary in vitro antibody response is profoundly decreased. We show that the removal of a nylon-adherent cell restores this response. The suppressor cell is plastic adherent, phagocytic non-T and radio-resistant, thus probably a monocyte. Its effect is inhibited by indomethacin, which suggests that its action if mediated by prostaglandins.
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