[Effect of cholinomimetics on the rate of hypothermia development]

The rate of hypothermia development was studied in different stages--mild, medium and deep--corresponding with rectal temperatures of 33, 26 and 19 degrees C. This rate significantly decreases in mild hypothermia induced by nicotine (4 mg/kg), in medium hypothermia induced by nicotine and pilocarpine (25 mg/kg), and methacin (20 mg/kg) combined with arecoline (20 mg/kg), in deep hypothermia induced by methacin coupled with arecoline, and significantly rises in deep hypothermia induced by methacin (20 mg/kg) combined with proserin (0.45 mg/kg).