Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular control by medullary surface chemoreceptors.

F Lioy, B D Hanna, C Polosa

    Journal of the Autonomic Nervous System
    |February 1, 1981
    PubMed
    Summary

    Chemoreceptors on the ventral medulla regulate cardiovascular function. Stimulating these chemoreceptors with acid or alkaline solutions altered blood pressure, heart rate, and blood flow in cats.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary arterial hypertension associated with congenital heart disease and Eisenmenger syndrome: current practice in pediatrics.

    Minerva pediatrica·2015
    Same author

    Pulmonary complications of congenital heart disease.

    Paediatric respiratory reviews·2012
    Same author

    Cardiac rhythm disturbances among children with idiopathic congenital central hypoventilation syndrome.

    Pediatric pulmonology·2000
    Same author

    Heart rate variability in preterm brain-injured and very-low-birth-weight infants.

    Biology of the neonate·2000
    Same author

    Organization of the sympathetic innervation of the forelimb resistance vessels in the cat.

    Anesthesia and analgesia·1999
    Same author

    Synaptic inhibitory effects of edrophonium on sympathetic ganglionic transmission.

    Canadian journal of anaesthesia = Journal canadien d'anesthesie·1998

    Area of Science:

    • Neuroscience
    • Cardiovascular Physiology
    • Respiratory Physiology

    Background:

    • The ventral surface of the medulla oblongata plays a critical role in regulating cardiovascular and respiratory functions.
    • Chemoreceptors located on the ventral medulla are sensitive to changes in cerebrospinal fluid pH and PCO2.

    Purpose of the Study:

    • To investigate the cardiovascular and respiratory effects of superfusing the ventral medullary surface with acid hypercapnic and alkaline hypocapnic solutions.
    • To elucidate the role of medullary chemoreceptors in cardiovascular control after peripheral chemoreceptor and baroreceptor denervation.

    Main Methods:

    • Experiments were conducted on anesthetized, paralyzed, and artificially ventilated cats.
    • Peripheral chemoreceptors and baroreceptors were denervated by sectioning carotid sinus, aortic, and cervical vagus nerves.
    • Systemic arterial pressure, central venous pressure, hindquarters blood flow, heart rate, and phrenic nerve activity were monitored.

    Main Results:

    • Acid hypercapnic superfusion (pH 6.8, PCO2 85 mm Hg) led to increased systemic arterial pressure, phrenic nerve activity, and heart rate, with decreased hindquarters blood flow.
    • Alkaline hypocapnic superfusion (pH u.i, PCO2 < 10 mmHg) produced opposite effects on these physiological parameters.
    • These findings demonstrate a significant role for ventral medullary chemoreceptors in modulating cardiovascular responses.

    Conclusions:

    • Chemoreceptors on the ventral surface of the medulla are crucial for cardiovascular regulation.
    • Modulation of medullary chemoreceptor stimulation directly impacts systemic hemodynamics and autonomic outflow.
    • These findings highlight the central nervous system's role in maintaining cardiovascular homeostasis.

    Related Experiment Videos