Evidence for an H-2-linked Ir gene regulating the immune response to a TI-2 antigen, DNP-Ficoll

Various H-2 congenic mouse pairs were immunized with 10 microgram of DNP53-Ficoll, a thymic independent (TI-2) antigen. Four-day primary splenic immune responses were measured by a DNP-reactive PFC assay. Significantly different responses were noted between partners of many congenic pairs. An H-2 linked Ir gene for DNP-Ficoll appears likely.