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Published on: October 11, 2013
In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva
Journal of Medicinal Chemistry
|March 1, 1981
Abstract:
A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.
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